The IMS houses the Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories (IMS-MRL) on two of its floors. IMS-MRL researchers undertake laboratory and clinical research into a range of metabolic and endocrine diseases. The IMS-MRL also hosts the MRC Metabolic Disease Unit. Professor Sir Stephen O’Rahilly is director of both the IMS-MRL and the MRC Metabolic Disease Unit.

A further floor houses the MRC Epidemiology Unit, directed by Professor Nick Wareham, whose scientists use epidemiological methods to study the aetiology and prevention of obesity and Type 2 diabetes.

The ground floor contains the IMS Clinical Care Centre, which incorporates the Wolfson Diabetes and Endocrine Clinic and the Weston Centre for Childhood and Adolescent Diabetes and Endocrinology. Together, these provide state-of-the-art NHS facilities for the treatment of people of all ages with diabetes obesity and related metabolic and endocrine disorders.

Major goals of the IMS include promoting top quality basic and clinical research in metabolic disease and, equally importantly, encouraging productive interaction between basic and clinical scientists to maximise the impact of research into the prevention and treatment of these diseases, and to improve the quality of care for individual patients.