evaluates population interventions in dietary public health
studies the genetic bases of common and rare forms of metabolic disease.
investigates how nutrients are detected by the brain to maintain energy homeostasis in health and disease.
develops and evaluates different methods for assessing physical activity in epidemiological studies with a view to assessing how activity relates to improving health.
investigates disorders of thyroid hormone action and the role of nuclear receptors in human disease.
studies the molecular mechanisms controlling food intake and energy expenditure.
looks at the role of epigenetics and imprinted genes in foetal growth and metabolism.
focuses on Type 1 diabetes and its complications, and the developmental origins of Type 2 diabetes.
studies hypoglycaemia and glucose sensing in the brain and improving type 1 diabetes management with new technologies.
investigates the molecular and physiological pathways involved in regulating human appetite and body weight.
aims to understand choice, behaviour and variability in susceptibility to internally- and environmentally-driven food consumption.
investigates the role that diet and nutrition plays in the risk of developing diabetes, obesity and obesity-related disorders.
explores how gut hormones are released and their actions on target tissues.
investigates prevention, early detection and management of obesity and type 2 diabetes.
focuses on optimising the diagnosis and treatment of disorders of the pituitary and adrenal glands.
is developing closed-loop systems (Artificial Pancreas) that could serve as a ‘bridge’ until a cure in the form of either stem cell therapy or islet transplantation becomes available.
investigates how genetic and lifestyle factors act together in their influence on type 2 diabetes and related metabolic disorders.
studies the molecular and cellular basis of human disease, in particular obesity associated with the aberrant function of specific neuron types in the hypothalamus.
aims to characterise a new form of protein transport mechanism.
investigates the effects of interventions to influence the wider environmental or societal determinants of active living and associated behavioural and health outcomes.
investigates how early life factors, such as infant weight gain, diet and pubertal timing lead to later obesity and develops and tests preventative strategies.
focuses on molecular mechanisms in human obesity and insulin resistance, and translating this into improvements in diagnosis and therapy.
studies how poor nutrition and obesity during early life influences long-term risk of developing Type 2 diabetes, obesity and cardiovascular disease.
identifies mechanisms underlying the secretion of peptides with regulatory roles in metabolism.
researches the molecular events underpinning human insulin resistance and its contribution to the pathogenesis of Type 2 diabetes.
aims to elucidate the genetic basis of congenital hypothyroidism by identifying and characterising genes causing the disorder.
focuses on the genetic, cellular and molecular basis of human genetic disorders of insulin action, from severe insulin resistance to spontaneous non-insulin-dependent hypoglycaemia.
studies the receptors and signalling mechanisms mediating the effects of insulin and IGFs on cellular metabolism and growth.
leads the MRC Epidemiology Unit’s Global Public Health Research initiatives.
develops and evaluates interventions to promote physical activity in young people, and uses observational research to further understand where, when and how physical activity interventions in young people may be targeted.
investigates the role of lipotoxicity in the pathogenesis of obesity and the Metabolic Syndrome and on developing novel therapeutic approaches.
investigates the association of genes with type 2 diabetes and examines how these associations are modified by environmental factors, such as diet and physical activity.
focuses on understanding the determinants of behaviour and the development and evaluation of interventions that impact dietary behaviours.
works with models to help understand both the health impacts of changes to how we travel and how we eat and to understand how such changes might occur.
studies the molecular mechanisms underlying the central control of food intake.