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Our Lead Researchers

Dr Ines Barroso studies the genetic bases of common and rare forms of metabolic disease.	Dr Soren Brage develops and evaluates different methods for assessing physical activity in epidemiological studies with a view to assessing how activity relates to improving health.	Prof Krishna Chatterjee investigates the role of nuclear receptors in human disease.
Dr Tony Coll studies the molecular mechanisms controlling food intake and energy expenditure.	Dr Miguel Constancia looks at the role of epigenetics and imprinted genes in foetal growth and metabolism.	Professor David Dunger focuses on Type 1 diabetes and its complications, and the developmental origins of Type 2 diabetes.
Dr Ulf Ekelund investigates how physical activity and sedentary behaviour affects the health of people across their lifespan with particular reference to the development of metabolic disease.	Dr Mark Evans studies glucose-sensing in the brain, and improving Type 1 diabetes management using closed-loop insulin pump systems.	Professor Sadaf Farooqi investigates the molecular and physiological pathways involved in regulating human appetite and body weight.
Dr Nita Forouhi investigates the role that diet and nutrition plays in the risk of developing diabetes, obesity and obesity-related disorders.	Dr Simon Griffin translates knowledge gained from epidemiological studies into action to prevent diabetes, obesity and related metabolic disorders and assesses the effectiveness of different approaches to prevent these conditions and their complications.	Dr Roman Hovorka is developing closed-loop systems (Artificial Pancreas) that could serve as a ‘bridge’ until a cure in the form of either stem cell therapy or islet transplantation becomes available.
Dr Claudia Langenberg investigates how genetic and lifestyle factors act together in their influence on type 2 diabetes and related metabolic disorders.	Dr Helen Murphy is working to improve the health outcomes for women and children with Type 1 diabetes.	Dr David Ogilvie investigates the effects of interventions to influence the wider environmental or societal determinants of active living and associated behavioural and health outcomes.
Dr Ken Ong investigates how early life factors, such as infant weight gain, diet and pubertal timing lead to later obesity and develops and tests preventative strategies.	Professor Steve O'Rahilly focuses on molecular mechanisms in human obesity and insulin resistance, and translating this into improvements in diagnosis and therapy.	Dr Sue Ozanne studies how poor nutrition during early life influences long-term risk of developing Type 2 diabetes, obesity and cardiovascular disease.
Dr Ak Reddy investigates the molecular mechanisms of circadian clocks and how these control aspects of our physiology, including endocrine parameters, metabolism and the sleep-wake cycle.	Dr Justin Rochford studies how defects in adipocyte development and function are involved in human metabolic disease.	Professor David Ron investigates signalling pathways in the cellular adaptation to proteotoxicity.
Dr David Savage researches the molecular events underpinning human insulin resistance and its contri­bution to the pathogenesis of Type 2 diabetes	Dr Rob Semple focuses on the genetic, cellular and molecular basis of human genetic disorders of insulin action, from severe insulin resistance to spontaneous non-insulin-dependent hypoglycaemia.	Dr Jazz Sethi studies Wnt and TNFa signalling in tissue remodelling and metabolic disease.
Professor Ken Siddle studies the receptors and signalling mechanisms mediating the effects of insulin and IGFs on cellular metabolism and growth.	Dr Esther Van Sluijs identifies individual, social and environmental correlates and determinants of young people's physical activity behaviour to inform intervention development and evaluates physical activity promotion interventions.	Professor Toni Vidal-Puig - investigates the role of lipotoxicity in the pathogenesis of obesity and the Metabolic Syndrome and on developing novel therapeutic approaches.
Professor Nick Wareham investigates the association of genes with type 2 diabetes and examines how these associations are modified by environmental factors, such as diet and physical activity.	Dr Giles Yeo studies the molecular mechanisms underlying the central control of food intake.